Strong Eukaryotic IRESs Have Weak Secondary Structure
Xuhua Xia, Martin Holcik · 2009
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Description
Xuhua Xia and Martin Holcik published this study in PLOS ONE in 2009. Some messenger RNAs can start protein building at an internal site called an IRES, instead of at the usual front end. The authors set out to test the idea that strong IRES sites in eukaryotes lack folded structure.
They also checked how widely that idea holds. They looked at IRES sites from yeast and the fruit fly, which sit just before the protein-coding section. Comparing strong and weak sites, they link strength to weaker folding in the RNA. The paper gives researchers a structural clue for spotting and designing these internal start sites.
Catalog record
| CREATOR | Xuhua Xia, Martin Holcik |
|---|---|
| YEAR | 2009 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 15 KB |
| LICENSE | Creative Commons Attribution License |
| RIGHTS | CC BY |
| SOURCE | PLOS ONE |
Source: https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0004136