Axon Myelin Transfer of a Non-Enveloped Virus
Jean-Pierre Roussarie, Claude Ruffié, Julia M. Edgar et al. · 2007
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Description
Theiler's virus is a mouse picornavirus that infects neurons and, unusually, passes from their axons into the surrounding myelin sheath. Jean-Pierre Roussarie and colleagues studied that transfer in a 2007 PLOS ONE article. Earlier work had shown the virus trafficking from the axon of infected neurons into myelin.
When this traffic is interrupted, as in the shiverer mouse, which carries a mutation in the myelin basic protein gene, the infection's course changes. The authors examine axon-to-myelin transfer of a non-enveloped virus, a route without obvious machinery. Theiler's virus is also a model for multiple sclerosis, which gives the work a second audience.
Catalog record
| CREATOR | Jean-Pierre Roussarie, Claude Ruffié, Julia M. Edgar et al. |
|---|---|
| YEAR | 2007 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 15 KB |
| LICENSE | Creative Commons Attribution License |
| RIGHTS | CC BY |
| SOURCE | PLOS ONE |
Source: https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0001331