Phage-Antibiotic Synergy (PAS): β-Lactam and Quinolone Antibiotics Stimulate Virulent Phage Growth
André M. Comeau, Françoise Tétart, Sabrina N. Trojet et al. · 2007
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Description
André M. Comeau, Françoise Tétart, Sabrina N. Trojet and colleagues found that antibiotics can feed the viruses that kill bacteria, in PLOS ONE in 2007. Bacteriophages, viruses of bacteria, shape the biosphere hugely, yet comparatively little was known about how the external environment affects phage production. The team reports that sub-lethal concentrations of certain antibiotics can substantially stimulate phage growth.
Beta-lactam and quinolone antibiotics are named in the title, and the effect is called phage-antibiotic synergy. Stressed bacteria apparently become better phage factories. The synergy suggests pairing phages with antibiotics in therapy, where the drug boosts the phage precisely when bacteria are weakened. It also warns that antibiotic pollution may stir phage ecology.
Catalog record
| CREATOR | André M. Comeau, Françoise Tétart, Sabrina N. Trojet et al. |
|---|---|
| YEAR | 2007 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 21 KB |
| LICENSE | Creative Commons CC0 License |
| RIGHTS | CC0 |
| SOURCE | PLOS ONE |
Source: https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0000799