Selection against Spurious Promoter Motifs Correlates with Translational Efficiency across Bacteria
Jeffrey L. Froula, M. Pilar Francino · 2007
Read Selection against Spurious Promoter Motifs Correlates with Translational Efficiency across Bacteria by Jeffrey L. Froula, M. Pilar Francino (2007) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/plos-pone-0000745.txt.
Description
Jeffrey L. Froula and M. Pilar Francino found that bacteria purge fake gene-start signals, and that the purge tracks protein output. RNA polymerase, the enzyme that copies genes, can bind misplaced DNA sites and waste effort. Selection for efficient gene expression should therefore control where polymerase-binding motifs appear across the genome. The authors analyze the distribution of those motifs.
Their title states the pattern: selection against spurious promoter motifs correlates with translational efficiency across bacteria. In plain terms, genomes are proofread by evolution against costly distractions. The cleaner the genome, the better its genes seem to translate. It is a tidy link between genome hygiene and growth economics.
Catalog record
| CREATOR | Jeffrey L. Froula, M. Pilar Francino |
|---|---|
| YEAR | 2007 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 51 KB |
| LICENSE | Creative Commons CC0 License |
| RIGHTS | CC0 |
| SOURCE | PLOS ONE |
Source: https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0000745