HIV-1 Nef Binds the DOCK2–ELMO1 Complex to Activate Rac and Inhibit Lymphocyte Chemotaxis
Ajit Janardhan, Tomek Swigut, Brian Hill et al. · 2004
Read HIV-1 Nef Binds the DOCK2–ELMO1 Complex to Activate Rac and Inhibit Lymphocyte Chemotaxis by Ajit Janardhan, Tomek Swigut, Brian Hill et al. (2004) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/plos-pbio-0020006.txt.
Description
Ajit Janardhan, Tomek Swigut, Brian Hill, and co-workers studied an HIV protein in PLOS Biology in 2004. The protein, Nef, helps HIV spread and weaken the immune system. The team found that Nef grabs a pair of host proteins, DOCK2 and ELMO1, inside immune cells.
That grip switches on a protein called Rac and changes how the cell moves. Infected T cells then fail to move toward chemical signals as they should. A virus that slows the movement of immune cells gains room to spread. The finding maps one exact contact HIV makes with its host. Contacts like that are possible drug targets, since blocking them might restore normal immune cell behavior.
Catalog record
| CREATOR | Ajit Janardhan, Tomek Swigut, Brian Hill et al. |
|---|---|
| YEAR | 2004 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 63 KB |
| LICENSE | Creative Commons Attribution License |
| RIGHTS | CC BY |
| SOURCE | PLOS ONE |
Source: https://journals.plos.org/plosone/article?id=10.1371/journal.pbio.0020006