Long-term effects of tafamidis for the treatment of transthyretin familial amyloid polyneuropathy
Teresa Coelho, Luı́s F. Maia, ANA CESARINA FERREIRA DA SILVA, Márcia Waddington‐Cruz, Violaine Planté‐Bordeneuve, Ole Bernt Suhr, Isabel M. Conceição, Hartmut Schmidt, Pedro Trigo, Jeffery W. Kelly, Richard F. Labaudinière, Jason Chan · 2013
Read Long-term effects of tafamidis for the treatment of transthyretin familial amyloid polyneuropathy by Teresa Coelho, Luı́s F. Maia, ANA CESARINA FERREIRA DA SILVA, Márcia Waddington‐Cruz, Violaine Planté‐Bordeneuve, Ole Bernt Suhr, Isabel M. Conceição, Hartmut Schmidt, Pedro Trigo, Jeffery W. Kelly, Richard F. Labaudinière, Jason Chan (2013) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/openalex-w2080914865.txt.
Description
Teresa Coelho, Luis Maia, Ana Martins da Silva and colleagues studied long-term treatment for a rare nerve disease. Their paper appeared in Journal of Neurology in 2013. The disease runs in families and damages peripheral nerves. A faulty protein slowly harms nerves over years. The drug tafamidis stabilises that protein.
Patients from an earlier trial continued into this extension study. Some stayed on tafamidis, while others switched from placebo. Nerve scores stayed roughly stable in long-treated patients. Patients who switched later also slowed in decline. Early starters kept more nerve function overall. Side effects were similar between groups. No one stopped treatment because of side effects. Earlier treatment gave the greatest benefit.
Catalog record
| CREATOR | Teresa Coelho, Luı́s F. Maia, ANA CESARINA FERREIRA DA SILVA, Márcia Waddington‐Cruz, Violaine Planté‐Bordeneuve, Ole Bernt Suhr, Isabel M. Conceição, Hartmut Schmidt, Pedro Trigo, Jeffery W. Kelly, Richard F. Labaudinière, Jason Chan |
|---|---|
| YEAR | 2013 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 53 KB |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | OpenAlex / Journal of Neurology |