antiSMASH 3.0-a comprehensive resource for the genome mining of biosynthetic gene clusters.
Weber T, Blin K, Duddela S, Krug D, Kim HU, Bruccoleri R, Lee SY, Fischbach MA, Müller R, Wohlleben W, Breitling R, Takano E, Medema MH. · 2015
Read antiSMASH 3.0-a comprehensive resource for the genome mining of biosynthetic gene clusters. by Weber T, Blin K, Duddela S, Krug D, Kim HU, Bruccoleri R, Lee SY, Fischbach MA, Müller R, Wohlleben W, Breitling R, Takano E, Medema MH. (2015) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/europmc-pmc4489286.txt.
Description
Tilmann Weber and a team of co-authors released antiSMASH 3.0 in Nucleic Acids Research in 2015, a resource for mining microbial genomes. Microbes make many valuable compounds, antibiotics, cancer drugs, insecticides, through gene clusters that encode a whole production line. Finding those clusters in a genome is a key step in discovering new compounds, and antiSMASH, launched in 2011, automates the search and analysis.
Version 3.0 integrates a probabilistic algorithm that can detect clusters of unknown types, not just known families. A new comparison module matches found clusters against more than a thousand clusters whose end products are known, helping judge novelty. At the enzyme level, the active sites of key building enzymes are now pinpointed by curated patterns, and every enzyme gene receives a functional classification number. The authors present the update as a comprehensive genome mining workbench.
Catalog record
| CREATOR | Weber T, Blin K, Duddela S, Krug D, Kim HU, Bruccoleri R, Lee SY, Fischbach MA, Müller R, Wohlleben W, Breitling R, Takano E, Medema MH. |
|---|---|
| YEAR | 2015 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 22 KB |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |