Inducing autophagy by rapamycin before, but not after, the formation of plaques and tangles ameliorates cognitive deficits.
Majumder S, Richardson A, Strong R, Oddo S. · 2011
Read Inducing autophagy by rapamycin before, but not after, the formation of plaques and tangles ameliorates cognitive deficits. by Majumder S, Richardson A, Strong R, Oddo S. (2011) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/europmc-pmc3182203.txt.
Description
Smita Majumder and colleagues tested timing in Alzheimer prevention using a mouse model in a 2011 paper in PLoS ONE. Boosting the cell's recycling system had eased early memory problems tied to soluble toxic protein, but established plaques and tangles might be beyond rescue. They fed a recycling-boosting drug to Alzheimer-model mice either from youth or only once brain deposits were entrenched.
Lifelong early treatment switched recycling on, cut plaques and tangles substantially, and preserved cognition. Starting the same drug in old mice with full-blown deposits changed none of those outcomes. The contrast draws a hard line: recycling-based therapy looks valid only early in disease progression, before deposits consolidate, which reshapes how such drugs should be trialled in people.
Catalog record
| CREATOR | Majumder S, Richardson A, Strong R, Oddo S. |
|---|---|
| YEAR | 2011 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 64 KB |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |